Cleavage furrow positioning
نویسنده
چکیده
To complete the cell cycle, the cleavage furrow draws the plasma membrane toward the cell center, pinching the cytoplasm into two lobes that are subsequently separated into two cells. The position of the cleavage furrow is induced by the mitotic spindle during early anaphase. Although the mechanism of cleavage furrow positioning is not understood at a molecular level, recent results suggest that it might be mediated by local relief from the inhibitory effects of microtubules.
منابع مشابه
A spindle-independent cleavage furrow positioning pathway
The mitotic spindle determines the cleavage furrow site during metazoan cell division, but whether other mechanisms exist remains unknown. Here we identify a spindle-independent mechanism for cleavage furrow positioning in Drosophila neuroblasts. We show that early and late furrow proteins (Pavarotti, Anillin, and Myosin) are localized to the neuroblast basal cortex at anaphase onset by a Pins ...
متن کاملTwo-step positioning of a cleavage furrow by cortexillin and myosin II
BACKGROUND Myosin II, a conventional myosin, is dispensable for mitotic division in Dictyostelium if the cells are attached to a substrate, but is required when the cells are growing in suspension. Only a small fraction of myosin II-null cells fail to divide when attached to a substrate. Cortexillins are actin-bundling proteins that translocate to the midzone of mitotic cells and are important ...
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RhoA controls cleavage furrow formation during cell division, but whether RhoA suffices to orchestrate spatiotemporal dynamics of furrow formation is unknown. In this issue, Wagner and Goltzer (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201603025) show that RhoA activity can induce furrow formation in all cell cortex positions and cell cycle phases.
متن کاملProper positioning of the cleavage furrow requires a-actinin to regulate the specification of different populations of microtubules
Vinayaka Srinivas and Maki Murata-Hori* Cell Biology Program, Temasek Life Sciences Laboratory, The National University of Singapore, 1 Research Link, 117604 Singapore Department of Biological Sciences, The National University of Singapore, 1 Research Link, 117604 Singapore Present address: Institute for Stem Cell Biology and Regenerative Medicine, National Centre for Biological Sciences, Tata ...
متن کاملFocal adhesions control cleavage furrow shape and spindle tilt during mitosis
The geometry of the cleavage furrow during mitosis is often asymmetric in vivo and plays a critical role in stem cell differentiation and the relative positioning of daughter cells during development. Early observations of adhesive cell lines revealed asymmetry in the shape of the cleavage furrow, where the bottom (i.e., substrate attached side) of the cleavage furrow ingressed less than the to...
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ورودعنوان ژورنال:
- The Journal of Cell Biology
دوره 164 شماره
صفحات -
تاریخ انتشار 2004